While most annual physicals check fewer than 20 markers, this Maine clinic runs 80+ on every new patient and pairs it with a 60-minute provider consultation
SOUTH PORTLAND, Maine (June 2026) — A standard annual physical in the United States typically includes a basic metabolic panel, a lipid screen, and maybe a CBC. That’s roughly 15 to 20 markers. For most patients, it’s the only blood work they’ll see all year.
Med Matrix, a functional medicine clinic in South Portland, Maine, takes a different approach. Every new patient receives a blood panel covering more than 80 biomarkers, a full body composition scan, and a 60-minute consultation where providers walk through every single result.
The clinic has run this protocol on more than 3,000 patients since opening in July 2023.
What 80+ Markers Actually Covers
A standard lab panel checks the basics: cholesterol, blood sugar, kidney function, a red and white blood cell count. These markers tell a provider whether something is acutely wrong. They don’t reveal much about why a patient feels exhausted at 2pm every day, why their hair is thinning, or why they can’t lose weight despite doing everything right.
Med Matrix’s panel expands into areas that most primary care offices skip entirely:
A full thyroid panel that goes beyond TSH. Most doctors check TSH alone, which is a signaling hormone from the brain. It doesn’t measure T3 or T4 (the hormones that actually run metabolism, energy, and temperature regulation) or thyroid antibodies (which reveal autoimmune conditions like Hashimoto’s).
A complete hormone panel. Testosterone, estrogen, progesterone, DHEA, cortisol. For both men and women, these markers connect directly to energy, mood, body composition, sleep quality, and cognitive function.
Inflammatory markers like CRP and homocysteine. Chronic inflammation is linked to heart disease, autoimmune flares, joint pain, and fatigue. It rarely shows up on a standard panel.
Fasting insulin, not just fasting glucose. Blood sugar can look “normal” on paper while insulin is already climbing, a sign that metabolic dysfunction is developing years before a diabetes diagnosis.
Nutrient levels including vitamin D, B12, iron studies, and magnesium. Deficiencies in these markers drive symptoms that often get chalked up to aging or stress.
Why Standard Ranges Miss the Problem
Even when a broader panel is ordered, results are typically measured against “reference ranges,” which are population averages. A lab might flag testosterone as low only if it drops below 300 ng/dL. But a man at 310 can feel terrible, and a man at 800 can feel great. Both are “normal” by the lab’s standards.
“Just because a number falls inside the reference range doesn’t mean it’s where that person functions best,” said Cole Siefer, founder of Med Matrix. “We look at optimal ranges, not just whether something is technically flagged.”
This distinction explains a frustration that many patients share: their doctor tells them everything looks fine, but they don’t feel fine. The labs aren’t wrong. The ranges are too wide.
The Body Composition Scan
In addition to blood work, every new patient at Med Matrix receives a full body composition scan. The scan measures lean muscle mass, fat distribution, visceral fat levels, and hydration, providing a baseline that blood work alone can’t capture.
This is particularly relevant for patients on weight management programs, hormone therapy, or peptide therapy. Scale weight tells one story. Body composition tells a more complete one.
“Someone can lose five pounds on the scale and think nothing happened,” Siefer said. “But the scan shows they gained three pounds of muscle and lost eight pounds of fat. That’s a completely different picture.”
The 60-Minute Consultation
Lab results alone don’t change outcomes. Someone has to explain them, connect the dots between markers, and build a plan.
At Med Matrix, every new patient gets a full hour with their provider. Before the appointment, the provider has already reviewed the labs, the scan, and the patient’s health history and symptom questionnaires. The visit itself is a working session where the patient and provider build a treatment plan together.
This is the part most patients say surprised them most. Not the number of markers tested, but the fact that someone sat with them for an hour and explained what every result means and why it matters.
A Model 3,000 Patients Have Chosen
Med Matrix has served more than 3,000 patients since July 2023, with over 200 new patients arriving each month. The clinic holds a 4.9-star rating across 150+ Google reviews.
The clinic’s 7 providers cover functional medicine, hormone therapy, peptide therapy, weight management, and aesthetic services, all operating from a single location in South Portland, Maine.
About Med Matrix
Med Matrix (medmatrixusa.com) is a functional medicine clinic in South Portland, Maine, founded in 2023 by Cole Siefer. The clinic specializes in root-cause healthcare, hormone therapy, advanced lab testing, and personalized treatment plans. With 7 providers and more than 3,000 patients served, Med Matrix has become one of New England’s fastest-growing functional medicine practices.
Media Contact:
Med Matrix South Portland, Maine
